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Senior Scientist / Scientist, In Vitro Pharmacology

Maze Therapeutics

This is a Contract position in South San Francisco, CA posted June 12, 2020.

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines.

We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking an experienced, highly motivated scientist with small molecule expertise and significant experience developing key biochemical and cell-based functional assays to drive lead optimization for programs across the portfolio.

The successful candidate will develop and perform medium and high throughput screening campaigns to collect compound activity data critical for early hit identification and lead optimization.

Adaptability to a startup environment is fundamental to the role, as you will play a significant role in compound assessment and generating key datasets for development candidates.

Your Role in Navigating the Maze: Develop, optimize and execute medium and high throughput screening campaigns to measure small molecule activity Work alongside automation and research infrastructure to develop production assays for data collection Implement in vitro models to determine on-target and off-target potency Characterize activity in detailed biochemical, cell or tissue-based functional follow-up assays across varied target classes Evaluate novel assay technologies for potential internalization or deployment with CROs Manage, process, analyze and present data to project teams Assist with the coordination of studies with CROs as necessary Your Navigation Tools: MS/PhD in relevant field with 5 years’ experience performing in vitro studies to measure compound activity Experience with small molecule assay development, optimization and screening Comprehensive working knowledge of biochemical/biomolecular and cell-based assays to interrogate targets Demonstrated understanding of automation as it relates to production assays Experience with mammalian cell culture Solid knowledge of pharmacology concepts including potency, PK, physiological endpoints Motivation to work on multiple project simultaneously and serve project teams to advance lead optimization programs Excellent communication skills and ability to work in a team-based environment Hands on, detail oriented and highly organized